Open AccessAssociation of Serum Albumin with Short-Term Outcome of Ischemic Stroke
Author(s) -
Bakhtiar Azam,
Afm Al Masum Khan,
Muhammad Enayet Hussain,
Riaz Ferdaus,
Sirajee Shafiqul Islam,
Atm Hasibul Hasan,
Amir Hossain,
Dewan Md Elyas,
Muhammad Abdul Momen Khan,
Khairul Kabir Patwari,
Mahmudul Haque,
Quazi Deen Mohammad
Publication year - 2019
Publication title -
journal of national institute of neurosciences bangladesh
Language(s) - English
Resource type - Journals
eISSN - 2518-6612
pISSN - 2410-8030
DOI - 10.3329/jninb.v5i2.43012
Subject(s) - medicine , modified rankin scale , confidence interval , odds ratio , logistic regression , stroke (engine) , neurology , ischemic stroke , brain ischemia , albumin , serum albumin , observational study , ischemia , psychiatry , mechanical engineering , engineering
Background: Serum albumin is proved to be a neuroprotective substance in experimental studies in focal cerebral ischemia.
Objective: The aim of this study was to find out any association of serum albumin with the short term outcome of ischemic stroke.
Methodology: This observational study was conducted in the Department of Neurology and Department of Internal Medicine at Dhaka Medical College Hospital, Dhaka from January 2011 to December 2011. A total of fifty consecutive patient with first ever ischemic stroke were included. Short term outcome was measured on day 7 using the modified Rankin Scale (mRS) and poor outcome was defined as mRS score 4 to 6 or death. Serum albumin was measured within 24 hours of onset of stroke.
Result: Serum albumin was found to be significantly associated with the short-term outcome of ischemic stroke [P-value of Chi square (df = 1) was 0.010]. On logistic regression analysis, SA level [p = 0.018, Odds Ratio (OR) =5.817; 95% confidence interval: 1.348 to 25.106] remained significantly and positively associated with the short-term outcome of ischemic stroke.
Conclusion: Serum albumin is significantly associated with the short-term outcome of ischemic stroke and lower level predicts poor outcome and higher level predicts good outcome.
Journal of National Institute of Neurosciences Bangladesh, 2019;5(2): 101-105