Open AccessClinical and Biochemical Characteristics and Aetiology of Asymptomatic Raised Alanine Aminotransferase in Newly Detected Diabetes and Impaired Glucose Tolerance Patients
Author(s) -
Mahbubur Rahman,
Golam Azam,
Nowshad Ali,
M Mohsin,
Shah Jamal,
Muhammad Abdur Rahim,
Habib Ben Ahmed,
Nazmul Hoque,
Tareq Mahmud Buiyan,
Anisur Rahman
Publication year - 2016
Publication title -
journal of bangladesh college of physicians and surgeons/journal of bangladesh college of physicians and surgeons
Language(s) - English
Resource type - Journals
eISSN - 2309-6365
pISSN - 1015-0870
DOI - 10.3329/jbcps.v33i2.28022
Subject(s) - medicine , impaired glucose tolerance , gastroenterology , asymptomatic , metabolic syndrome , diabetes mellitus , fatty liver , etiology , body mass index , impaired fasting glucose , abdominal obesity , liver disease , endocrinology , obesity , insulin resistance , disease
Objectives: Clinical evaluation and identification of aetiology of asymptomatic raised serum alanine aminotransferase (ALT) level in newly detected adult diabetic and impaired glucose tolerance (IGT) patients.Methods: In this cross-sectional study, newly detected adult diabetic and IGT patients having asymptomatic raised serum ALT level of > 1.5 times of upper limit of normal were evaluated clinically and by laboratory tests.Results: Total number of patients was 120, which was 3.1% of all newly registered diabetic and IGT patients over the study period. Male were 74 and female 46. Diabetes mellitus (DM) was found in 93.3% cases and IGT in 6.7%. Mean age was 43.1 years, mean body weight was 64.5 kg and mean body mass index (BMI) was 25.5 kg/m2. Central (abdominal) obesity was found in 61.5% cases. Increased waist hip ratio was found in 86.3% cases. Hypertension and hepatomegaly were present in 35% and 5.8% cases respectively. Dyslipidaemia was found in 98.3% cases and 45% patients fulfilled criteria for metabolic syndrome. Regarding etiology, 76.7% cases had non-alcoholic fatty liver disease (NAFLD), 8.3% had HBsAg sero-positivity, 4.2% had anti-HCV seropositivity and 3.3% had both NAFLD and HBsAg seropositivity. In 7.5% cases no cause was found. Raised serum ALT level had a significant correlation with metabolic syndrome (p= 0.016) and increasing age (p= 0.008).Conclusion: Elevation of serum ALT is common in DM and IGT. NAFLD is the commonest cause followed by hepatitis B and C virus infection.J Bangladesh Coll Phys Surg 2015; 33(2): 70-74