Open AccessA Screening Test for Iron Deficiency Anaemia and Thalassaemia Traits
Author(s) -
Amin Lutful Kabir,
Tashmim Farhana Dipta,
Hajera Khatun,
Mohammad Hafizur Rahman,
Mahfuz Haq,
Mohammad Kazim Uddin,
Mahmuda Begum
Publication year - 2015
Publication title -
journal of bangladesh college of physicians and surgeons/journal of bangladesh college of physicians and surgeons
Language(s) - English
Resource type - Journals
eISSN - 2309-6365
pISSN - 1015-0870
DOI - 10.3329/jbcps.v32i4.26063
Subject(s) - medicine , iron deficiency , predictive value , trait , erythrocyte fragility , population , thalassemia , iron deficiency anemia , serum iron , red cell , gastroenterology , anemia , hemolysis , environmental health , computer science , programming language
Both iron deficiency and thalassaemia trait can present with hypochromic microcytic morphology. Naked eye single tube red cell osmotic fragility (NESTROF) is an inexpensive and simple test which can effectively differentiate iron deficiency anaemia from thalassaemia trait. Our study was an opportunity to observe the role of NESTROF in screening of thalassaemia trait among our study population. Initially NESTROF was carried out in 677 patients (N) population of four groups having both positive and negative NESTORF; for economical issue, auto-analyzer study and haemoglobin electrophoresis were done among only 100 randomly selected subjects, who were finally included in our study as final study population (n). In our study, NESTROF was 94.23% sensitive and its specificity was 92.08%. The predictive value of a positive test was 88.13% and predictive value of a negative test was 96.24%. Our study showed, NESTROF can effectively differentiate iron deficiency anaemia (IDA) from thalassaemia trait but, is not effective in co-existent IDA and thalassaemia.J Bangladesh Coll Phys Surg 2014; 32: 190-193