Open AccessSpontaneous hypoglycemia: a review
Author(s) -
Sultana Marufa Shefin,
Nazmul Kabir Qureshi,
Ahmed Salam Mir,
Ahasnul Haq Amin,
Tareen Ahmed,
Faria Afsana,
Shah Alam,
Farhana Akter,
Shah Emran,
Tofazzal Hossain,
Shahjamal Khan,
Marufa Mustari,
Nusrat Sultana,
Mohammad Saifuddin,
Sadiqa Tuqan,
Shahjada Selim,
Samir Kumar Talukder,
Rafiq Uddin,
Feroz Amin
Publication year - 2019
Publication title -
imc journal of medical science
Language(s) - English
Resource type - Journals
eISSN - 2519-1721
pISSN - 2519-1586
DOI - 10.3329/imcjms.v13i1.42048
Subject(s) - hypoglycemia , medicine , insulinoma , hyperinsulinemic hypoglycemia , etiology , intensive care medicine , diabetes mellitus , differential diagnosis , glycemic , hyperinsulinism , insulin , pediatrics , endocrinology , pathology , insulin resistance
Spontaneous hypoglycemia is an important entity that may affect multiple organs. The differential diagnosis is broad in individuals with hypoglycemia in the absence of diabetes mellitus. Multiple etiologies may be present concurrently. Drugs, critical illnesses, hormone deficiencies, and non-islet cell tumors should be considered in those who are ill or taking medications. In apparently healthy individuals, endogenous hyperinsulinism due to insulinoma, functional β-cell disorders, or insulin autoimmune conditions are possible, as are accidental, surreptitious or factitious causes of hypoglycemia. Investigations should be guided by clinical scenario. Irrespective of the exact cause of the spontaneous hypoglycemia, treatment consists of correcting the glycemic state and preventing recurrence by alleviating underlying pathology. This review discusses the causes, diagnosis and management of spontaneous hypoglycemia.
IMC J Med Sci 2019; 13(1): 001