Open AccessSoluble Drug Theophylline Sodium Glycinate from Different Suppository Bases
Author(s) -
Faruk Ahmed,
SM Ashraful Islam,
Mohiuddin Quadir,
Md. Selim Reza
Publication year - 2007
Publication title -
the dhaka university journal of pharmaceutical sciences
Language(s) - English
Resource type - Journals
eISSN - 1816-1839
pISSN - 1816-1820
DOI - 10.3329/dujps.v3i1.182
Subject(s) - carnauba wax , wax , chemistry , suppository , stearic acid , beeswax , peg ratio , chromatography , dissolution , theophylline , nordihydroguaiaretic acid , flurbiprofen , dosage form , organic chemistry , pharmacology , arachidonic acid , economics , enzyme , medicine , finance
Theophylline Sodium Glycinate (TSG) loaded lipid-based suppositories were prepared and the effects of suppository bases and release modifiers (PEG 1500 and HPMC 15 cps) on in vitro release of TSG were investigated. Suppositories containing 300 mg TSG were prepared by fusion method. Bees wax, Carnauba wax, Stearic acid and PEG 4000 were used as hydrophobic bases. In vitro dissolution was carried out in aqueous and buffered media of pH 6.8 for 2 hours. The results showed that, the release rate of TSG is considerably slow from beeswax, carnauba wax and stearic acid based devices. However, substantial TSG release was observed from PEG 4000 based systems. Incorporation of PEG 1500 in beeswax, carnauba wax and stearic acid based suppositories increased the rate and extent of TSG release in buffer media. Inclusion of HPMC 15 cps in PEG 4000 loaded suppositories released TSG at a faster rate. Drug release was linear for all the formulation except PEG 4000 systems, which released drug in a biphasic pattern both in aqueous and buffered environment. Rate and extent of drug release was found to be a function of pH of the dissolution media.
Key words: Theophylline sodium glycinate, Suppositories, In vitro release
Dhaka Univ. J. Pharm. Sci. Vol.3(1-2) 2004
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