Open AccessStudy of Bioactivities of Holarrhena pubescence Growing in Bangladesh
Author(s) -
Alamgir Kabir,
Mst. Marium Begum,
Tahiya Islam
Publication year - 2018
Publication title -
the dhaka university journal of pharmaceutical sciences
Language(s) - English
Resource type - Journals
eISSN - 1816-1839
pISSN - 1816-1820
DOI - 10.3329/dujps.v17i1.37129
Subject(s) - analgesic , bark (sound) , traditional medicine , chemistry , pharmacology , medicine , biology , ecology
The stem bark of Holarrhena pubescence was tested for anti-diabetic, analgesic, anti-inflammatory and antidiarrheal activities. After 1, 4 and 12 weeks of treatment protocol in alloxan-induced diabetic rats, it showed very negligible reduction of blood glucose level. In 12 weeks treatment protocol H. pubescence demonstrated that, the extract at 300 and 600 mg/kg bw can reduce blood glucose level by 3 and 4 mmol/l, respectively. Bark extract possessed strong analgesic, anti-diarrheal and mild anti-inflammatory activities. A dose of 600-mg/kg showed 69.50% (p<0.05) of writhing inhibition compared to indomethacin (73.76%) for acetic acid-induced analgesic method. In formalin-induced anti-nociception, the extract at 300 and 600 mg/kg bw showed dose dependent antinociception (67.42% and 69.007%, respectively, p < 0.05). The anti-diarrheal study demonstrated significant antidiarrheal potential in a dose dependent manner as demonstrated by reduction of defecation by 64.92% and 71.43%, for 300- and 600-mg/kg bw, respectively.Dhaka Univ. J. Pharm. Sci. 17(1): 131-137, 2018 (June)