Open AccessEffect of Pre-treatment with Moringa oleifera (Drumstick) Leaves on Diabetogenesis Produced by Alloxan in Rats
Author(s) -
Shamsun Nahar,
Feroza Parveen,
Ferdous Ara,
Ferdous Mahmud Faisal
Publication year - 2015
Publication title -
delta medical college journal
Language(s) - English
Resource type - Journals
eISSN - 2308-460X
pISSN - 2307-6615
DOI - 10.3329/dmcj.v3i2.24424
Subject(s) - moringa , alloxan , medicine , traditional medicine , blood sugar , diabetes mellitus , tail vein , body weight , biology , microbiology and biotechnology , endocrinology , in vivo
Background: Medicinal plants constitute an important source of potential therapeutic agents for diabetes.\ud\udObjective: In the study, we aimed to investigate the pre-treatment effect or preventive effects of Moringa oleifera (MO) leaves on blood sugar of rats.\ud\udMaterials and method: This experimental study was carried out in the department of Pharmacology and Therapeutics of Sir Salimullah Medical College in collaboration with Bangladesh Council of Scientific and Industrial Research (BCSIR), Dhaka. A total 24 long Evans rats were included in this study and divided in to four groups. Hyperglycemia was induced on rats using alloxan (100 mg/kg body weight, intraperitioneally). Blood sample was collected from tail vein by tail tipping method. Pre-treatment effect or preventive role of Moringa oleifera (drumstick) leaf powder on diabetogenesis produced by Alloxan in rats was tested by giving 50 mg/rat/day Moringa oleifera leaf powder for 14 days orally as pre-treatment along with standard rat feed. Then alloxan was administered intraperitoneally on 15th day of the experiment and 50mg/rat/day Moringa oleifera leaf powder was given for 7 days as post-treatment.\ud\udResults: No significant effect of MO on blood glucose level was observed on normal rats and non significant hypoglycaemic effect was found in rats that were pretreated with MO.\ud\udConclusion: The present study suggests that Moringa oleifera leaf powder did not produce any significant protective effect in diabetogenesis produced by alloxan though it has hypoglycaemic effect