Open AccessSynthesis and Biological Evaluation of Sugar Induced Thiazole Derivatives
Author(s) -
Mosharef Hossain Bhuiyan,
Mohammed Mahbubul Matin,
Afm Hafizur Rahman,
Rabiul Alam
Publication year - 2021
Publication title -
the chittagong university journal of science
Language(s) - English
Resource type - Journals
ISSN - 1561-1167
DOI - 10.3329/cujs.v41i1.51915
Subject(s) - thiazole , thiourea , cyclohexanone , chemistry , acetophenone , antimicrobial , glycoside , iodine , sugar , organic chemistry , amino acid , medicinal chemistry , biochemistry , catalysis
The starting materials, 2-amino-4-phenylthiazole and 2-amino-4,5,6,7-tetrahydrobenzo[d]thiazole, were prepared by reacting thiourea with acetophenone and cyclohexanone in the presence of iodine under heating on a water bath with occasional stirring, respectively. Reaction of 2-amino-4-phenylthiazole and 2-amino-4,5,6,7-tetrahydrobenzo[d]thiazole with various sugars afforded corresponding N-glycoside derivatives in good yields. The structures of the synthesized N-glycosides derivatives have been established on the basis of their IR and NMR spectral data. The obtained compounds were screened for their antimicrobial activity. Some of them were found to possess significant activities, when compared to standard drugs.
The Chittagong Univ. J. Sci. 40(1) : 68-84, 2019