Open AccessBlood Lactate Level as Predictor of Early Outcome after Off-Pump Coronary Artery Bypass Grafting
Author(s) -
Nasrin Aktar,
Abdur Rahim,
Aym Shahidullah,
Ahm Iftekher Hossain,
Farooq Ahmed
Publication year - 2020
Publication title -
cardiovascular journal
Language(s) - English
Resource type - Journals
eISSN - 2309-6357
pISSN - 2071-0917
DOI - 10.3329/cardio.v12i2.47989
Subject(s) - medicine , artery , inotrope , diabetes mellitus , mechanical ventilation , off pump coronary artery bypass , adverse effect , cardiology , bypass grafting , blood transfusion , surgery , anesthesia , endocrinology
Background: Identification of predictors of morbidity and mortality is an important issue for the management of cardiac surgical patients. Elevated lactate concentrations in the immediate postoperative period reflect unmet metabolic demand and may be associated with outcome.
Methods: A prospective observational study was carried out in the department of cardiac surgery, at National Heart Foundation Hospital& Research Institute(NHFH&RI), Dhaka. commencing from July 2016 to March 2018. In all Adult patients irrespective of sex undergoing elective off-pump coronary artery bypass grafting (OPCABG). Purposive sampling was applied with patient with blood lactate level < 3 mmol/L 6hours after shifting from OT to ICU in Group-A and blood lactate level ≥3mmol/l, 6hours after shifting to the ICU in Group-B.Postoperative early adverse outcomes were analyzed in both the patient groups.
Results: Blood lactate level 6 hours after ICU transfer is an independent predictor for prolonged mechanical ventilation time, (OR 2.540, 95% CI 1.781-3.621, p= <0.001).prolonged ICU stay, .(OR 1.767, 95% CI 1.348-2.315, p=< 0.001) pulmonary complication (OR 1.503, 95% CI 1.104-2.046, p= 0.010).and renal dysfunction(OR 1.460, 95% CI 1.156-1.843, p= 0.001). following off-pump coronary artery bypass grafting. Other risk factors for adverse outcome including, low LVEF, diabetes mellitus, blood transfusion and inotropic support were also found to be predictors of major complications in our study.
Conclusion: The findings of this study permits to conclude that blood lactate level 6hours after ICU transfer is associated with an increased risk of postoperative early adverse outcome after off-pump coronary artery bypass grafting. It is found that lactate is an independent predictor of major postoperative complications. So, achieving normal blood lactate level following OPCABG is essential for minimizing postoperative adverse outcome.
Cardiovasc. j. 2020; 12(2): 120-125