Open AccessDisseminated intravascular coagulation in acute promyelocytic leukaemia and its impact on the induction failure: a single centre study
Author(s) -
Fazlur Rahman,
Ahmed Imran Kabir,
M. R. Khan,
Abdul Aziz,
MN Baqui,
TF Dipta,
Abm Yunus
Publication year - 2014
Publication title -
bangladesh medical research council bulletin
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.136
H-Index - 19
eISSN - 2224-7238
pISSN - 0377-9238
DOI - 10.3329/bmrcb.v39i2.19642
Subject(s) - medicine , coagulopathy , disseminated intravascular coagulation , acute promyelocytic leukemia , mortality rate , gastroenterology , surgery , intensive care medicine , biochemistry , retinoic acid , chemistry , gene
Life-threatening coagulopathy associated with acute promyelocytic leukemia (APL) has been the defining clinical characteristic and is an important risk factor for fatal haemorrhage and early death. Pathogenesis of coagulopathy in APL is complex and mainly includes disseminated intravascular coagulation (DIC). The study was done to see the status of DIC and its impact on the outcome of APL in our setting. Among the total 60 patients, induction mortality rate was 30% and remission rate was 70%. The main cause of induction mortality was bleeding that accounts for 66.7% of mortality. DIC was present among 32 out of 60 patients (53.33%). Induction mortality has significant relationship to DIC as the induction mortality rate is 47% in patients with DIC and 11% in patient without DIC (P value 0.0009). Induction motality rate in low, intermediate and high risk group is 6.70%, 24% and 58% respectively (p value < 0.0001). Finally, risk group subclassification revealed presence of DIC in high risk group has the highest early mortality rate.