Synthesis of 1-phenyl-3, 4-dihydropyrimidine-2(1H)-ones derivatives under solvent free condition and their antimicrobial activity | Zendy

Kawsari Akhter | Zendy; Khorshada Jahan | Zendy; ME Halim | Zendy; Suraiya A. Shefa | Zendy; Samia Rifat | Zendy; KR Khan | Zendy; S. Mosaddeq Ahmed | Zendy; UKR Romman | Zendy

Open Access

Synthesis of 1-phenyl-3, 4-dihydropyrimidine-2(1H)-ones derivatives under solvent free condition and their antimicrobial activity

Author(s) -

Kawsari Akhter,

Khorshada Jahan,

ME Halim,

Suraiya A. Shefa,

Samia Rifat,

KR Khan,

S. Mosaddeq Ahmed,

UKR Romman

Publication year - 2019

Publication title -

bangladesh journal of scientific and industrial research

Language(s) - English

Resource type - Journals

eISSN - 2224-7157

pISSN - 0304-9809

DOI - 10.3329/bjsir.v54i1.40730

Subject(s) - thiourea , antimicrobial , ethyl acetoacetate , chemistry , catalysis , biginelli reaction , organic chemistry , solvent , nuclear chemistry

We report herein the use of nickel nitrate hexahydrate [Ni(NO3)2.6H2O] as a new catalyst for the one-pot Biginelli like reaction coupling of 1-phenyl thiourea, ethyl acetoacetate and aromatic aldehydes to afford the corresponding 1-phenyl-3,4-dihydropyrimidin-2(1H)-thiones under solvent free condition to avoid the usage of hazardous organic solvents. The synthesized compounds were evaluated for their antimicrobial activity by KIRBY-BAUER disk diffusion method. Most of the compounds showed good to moderate antimicrobial activity. Bangladesh J. Sci. Ind. Res.54(1), 47-54, 2019

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