Open AccessSynthesis of 1-phenyl-3, 4-dihydropyrimidine-2(1H)-ones derivatives under solvent free condition and their antimicrobial activity
Author(s) -
Khaleda Akhter,
Khurshid Jahan,
ME Halim,
Suraiya A. Shefa,
Samia Rifat,
KR Khan,
S.M. Zabed Ahmed,
Ukr Romman
Publication year - 2019
Publication title -
bangladesh journal of scientific and industrial research
Language(s) - English
Resource type - Journals
eISSN - 2224-7157
pISSN - 0304-9809
DOI - 10.3329/bjsir.v54i1.40730
Subject(s) - thiourea , antimicrobial , ethyl acetoacetate , chemistry , catalysis , biginelli reaction , organic chemistry , solvent , nuclear chemistry
We report herein the use of nickel nitrate hexahydrate [Ni(NO3)2.6H2O] as a new catalyst for the one-pot Biginelli like reaction coupling of 1-phenyl thiourea, ethyl acetoacetate and aromatic aldehydes to afford the corresponding 1-phenyl-3,4-dihydropyrimidin-2(1H)-thiones under solvent free condition to avoid the usage of hazardous organic solvents. The synthesized compounds were evaluated for their antimicrobial activity by KIRBY-BAUER disk diffusion method. Most of the compounds showed good to moderate antimicrobial activity.
Bangladesh J. Sci. Ind. Res.54(1), 47-54, 2019