In vitro anti-viral effect of fructopyrano-(1→4)-glucopyranose from Radix isatidis on infuenza virus A | Zendy

Qin Sun | Zendy; Pi-xian Shui | Zendy; Han-bin Li | Zendy; Si-jin Yang | Zendy; Minghua Liu | Zendy; Shi-jing Zhang | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

<i>In vitro </i>anti-viral effect of fructopyrano-(1→4)-glucopyranose from <i>Radix isatidis</i> on infuenza virus A

Author(s) -

Qin Sun,

Pi-xian Shui,

Han-bin Li,

Si-jin Yang,

Minghua Liu,

Shi-jing Zhang

Publication year - 2012

Publication title -

bangladesh journal of pharmacology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.385

H-Index - 23

eISSN - 1991-0088

pISSN - 1991-007X

DOI - 10.3329/bjp.v7i3.11228

Subject(s) - in vitro , virus , hemagglutinin (influenza) , neuraminidase , influenza a virus , radix (gastropod) , virology , biology , chemistry , biochemistry , botany

To investigate the in vitro anti-viral effect of fructopyrano-(1→4)-glucopyranose (FG) from traditional Chinese medicine Radix isatidis, dog kidney cells (MDCK) were with treated with either FG and then with virus (Group A); virus and then with FG (Group B); or FG and virus simultaneous-ly (Group C). Results showed the in vitro cell protection rate and virus inhibition rate increased significantly with the increase of FG concentration when compared with cells without FG treatment (p<0.01). The anti-viral effect was the best in Group C and that in Group A was superior to that in Group B. FG could exert significant inhibited effect on neuraminidase activity with the IC50 of 0.07 mmol/mL and on hemagglutinin of avian influenza virus with minimum inhibitory concentration of 3.13 mg/mL. Our findings indicate FG can confer obvious antiviral effects on influenza A virus in vitro

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research