Open AccessAnti-cancer effect of Atractylodes macrocephala extract by double induction of apoptotic and autophagic cell death in head and neck cancer cells
Author(s) -
Ni Kou,
Hyejoung Cho,
Hye-Eun Kim,
Qiaochu Sun,
Kyuhyeon Ahn,
Hyeongjoon Ji,
Hongran Choi,
Ok-Su Kim
Publication year - 2017
Publication title -
bangladesh journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.385
H-Index - 23
eISSN - 1991-0088
pISSN - 1991-007X
DOI - 10.3329/bjp.v12i2.31238
Subject(s) - apoptosis , head and neck squamous cell carcinoma , autophagy , pi3k/akt/mtor pathway , cancer , medicine , programmed cell death , cancer cell , protein kinase b , cancer research , cell culture , head and neck cancer , cell , traditional medicine , biology , biochemistry , genetics
The apoptosis resistance restricts the efficacy of traditional therapies of head and neck squamous cell carcinoma (HNSCC). To overcome this problem, Atractylodes macrocephala, a traditional Korean and Chinese herbal medicine, has been used in clinical practice. In the present study, the anticancer effect of A. macrocephala extract was investigated and its underlying mechanisms using head and neck cancer KB cell line. The extract-induced cytotoxicity was mediated by autophagic cell death as well as apoptosis in HNSCC cells though extrinsic apoptotic pathway and the Akt/mTOR autophagic pathway. This study suggests that A. macrocephala extracts can be a potential drug to overcome side effects and susceptibility for head and neck carcinoma by double induction of apoptosis and autophagy