Open AccessSynthesis, characterization, and anti-plasmodial activity of 2,6-substituted benzothiazole derivatives
Author(s) -
S. Gnanavel,
Kannan Kulanthai,
Rajamani Sowmiya,
Pachiappan Perumal
Publication year - 2016
Publication title -
bangladesh journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.385
H-Index - 23
eISSN - 1991-0088
pISSN - 1991-007X
DOI - 10.3329/bjp.v11i2.24886
Subject(s) - benzothiazole , chemistry , stereochemistry , giemsa stain , biochemistry , biology , genetics
Six compounds of benzothiazole derivatives were synthesized, and structures were confirmed by FT-IR, 1H-NMR, 13C-NMR and LC-MS. The resulting compounds were evaluated for anti-plasmodial activity against Plasmodium falciparum by Giemsa stain. Among them the compounds 3b and 4 showed potent anti-plasmodial activity against P. falciparum. The compounds 3a, 5a, 5b also showed moderate anti-plasmodial activity. The structure-activity relationships of benzothiazole derivatives also discussed which were useful for exploring and developing benzothiazole derivatives as novel anti-malarial drugs