Open AccessHypoglycemic effect of poly-herbal combination in streptozotocin-induced diabetic rats
Author(s) -
Gino A. Kurian
Publication year - 2016
Publication title -
bangladesh journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.385
H-Index - 23
eISSN - 1991-0088
pISSN - 1991-007X
DOI - 10.3329/bjp.v11i2.24855
Subject(s) - tinospora cordifolia , streptozotocin , curcuma , alkaline phosphatase , medicine , pharmacology , cholesterol , traditional medicine , chemistry , diabetes mellitus , endocrinology , biochemistry , enzyme
The present study evaluates the combinatorial effect of a poly-herbal combination with multiple therapeutic effects as a hypoglycemic and hypolipidemic agent. Herbal combination of Salacia oblonga, Tinospora cordifolia, Emblica officinalis, Curcuma longa and Gymnema sylvestre was prepared and administered to streptozotocin (55 mg/kg, i.p.)-induced diabetic rats, at a dose of 100 mg/kg, for four weeks. The poly-herbal combination significantly elevated the plasma insulin (90%) and reduced serum glucose (42%), cholesterol (49%), triglycerides (43%), LDL cholesterol (62.5%) and plasma apo B/apo A in the diabetic rats. The liver lipogenic enzymes like HMG CoA reductase and glucose-6-phosphatase significantly declined (p<0.05) in their activity while glucose-6-phosphate dehydrogenase and malic enzymes showed higher activity compared to the diabetic control. The results suggest a significant hypoglycemic and hypolipidemic property for the poly-herbal combination