Open AccessGut modulator effect of methanolic extract of <i>Solanum surattense</i> explains its traditional use in constipation and diarrhea
Author(s) -
Shumaila Andleeb,
Muhammad Masood Ahmed,
Musaddique Hussain
Publication year - 2016
Publication title -
bangladesh journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.385
H-Index - 23
eISSN - 1991-0088
pISSN - 1991-007X
DOI - 10.3329/bjp.v11i1.24343
Subject(s) - verapamil , chemistry , zoology , medicine , loperamide , diarrhea , endocrinology , biology , calcium
Current research was conducted to find out the pharmacological basis of the methanolic extract of Solanum surattense for its traditional uses in constipation and diarrhea. In isolated rabbit jejunum preparations, S. surattense exhibited the spasmogenic effect at lower concentration (0.01-1.0 mg/mL) followed by the spasmolytic effect at next higher concentration (3-5 mg/mL) with EC 50 value of3.17 mg/mL. S. surattense and verapamil (standard Ca 2+ channel blocker) caused an inhibition of K + (80 mM)-induced contractions with EC 50 value of0.85 and 0.15 mg/mL respectively, suggesting Ca 2+ channels block-ade.Extract caused the rightward shift in Ca 2+ concentration-response curve, similar to verapamil. Among the fractions, aqueous fraction showed the spasmogenic effect while dichloromethane fraction showed spasmolytic effect. It is concluded that methanolic extract of S. surattense contains spasmogenic and spasmolytic constituents, which explains its traditional uses in constipation and diarrhea.