Open AccessAntiviral mode of action of <i>Lactobacillus plantarum</i> YML009 on Influenza virus H1N1
Author(s) -
Irfan A. Rather,
KwangDong Choi,
Vivek K. Bajpai,
Yong-Ha Park
Publication year - 2015
Publication title -
bangladesh journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.385
H-Index - 23
eISSN - 1991-0088
pISSN - 1991-007X
DOI - 10.3329/bjp.v10i2.23068
Subject(s) - virus , lactobacillus plantarum , microbiology and biotechnology , influenza a virus , probiotic , nutraceutical , bacteria , virology , biology , lactic acid , food science , genetics
The development of resistance against antiviral agents has augmented a threat to public health sector. Consequently there is an expanding demand for the development of unconventional antiviral agents that could efficiently replace the existent in-use drugs. The probiotic strains of lactic acid bacteria (LAB) have earned the status of being efficient, economical and safe “nutraceutical” in health care armamentarium. A total of 2272 LAB strains were screened against H1N1 virus. The isolate YML009 displayed a pronounced antiviral activity. Sequencing and biochemical assays identified the isolate as Lactoballius plantarum which, exhibited resistance to the damage caused by the acidic conditions such as gastric juice and 5% bile salt. The anti-H1N1 activity of the strain was confirmed by hemagglutination assay and was found to display enhanced efficacy in comparison to the commercially available antiviral drug. This is a primary report on anti-influenza activity of a bacterium L. plantarum YML009