Open Access<i>In vitro</i> inhibitory potential of methanolic extract of <i>Celosia argentea</i> var. <i>cristata</i> on tyrosinase, acetylcholinesterase and butyrylcholinesterase enzymes
Author(s) -
Fatima Saqib,
Khalid Hussain Janbaz,
Maryam Khan Sherwani
Publication year - 2015
Publication title -
bangladesh journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.385
H-Index - 23
eISSN - 1991-0088
pISSN - 1991-007X
DOI - 10.3329/bjp.v10i2.22880
Subject(s) - tyrosinase , acetylcholinesterase , traditional medicine , chemistry , inhibitory postsynaptic potential , biology , biochemistry , enzyme , medicine , endocrinology
In the current study, methanol extract of Celosia argentea var. cristata was tested for its inhibitory potential against tyrosinase, acetylcholinesterase and butyrylcholinesterase enzymes at the concentration of 0.5 mM by ELISA microtiter plate assays. A significant tyrosinase inhibitory activity (63.6%), acetylcholinesterase inhibitory activity (80.3%) and butyrylcholinesterse inhibitory activity (68.24%) was shown by crude methanolic extract of C. argentea var. cristata with respective IC50 values of 268.5 ± 0.2 µg/mL, 73.6 ± 0.1 µg/mL and 132.8 ± 0.9 µg/mL. The result of this study reveals the use of C. argentea var. cristata in skin hyperpigmentation, Parkinson’s disease and neurodegenerative disorders like Alzheimer’s disease and dementia