Open AccessOver-expression of phosphorylated MARCKS in the nicotine-derived nitrosamine ketone induced lung cancer mice
Author(s) -
Zhen Chen,
Ling-Yun Gu,
Jun Zhou,
Qin Wang,
Hui Gao,
YU Zhong-he
Publication year - 2015
Publication title -
bangladesh journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.385
H-Index - 23
eISSN - 1991-0088
pISSN - 1991-007X
DOI - 10.3329/bjp.v10i1.21185
Subject(s) - lung cancer , carcinogen , nitrosamine , marcks , lung , immunohistochemistry , nicotine , cancer , population , cancer research , phosphorylation , medicine , chemistry , pathology , biochemistry , protein kinase c , environmental health
Lung cancer is the most frequently occurring lethal cancers in men and women population. The aim of the present study is to observe the over-expression pattern of phosphorylated MARCKS in the nicotine-derived nitrosamine ketone (NNK) induced lung cancer mice. Pathogen-free female A/J mice were used for the present experiment to induce lung cancer by the carcinogen namely, NNK. At different time intervals namely, 5th, 6th and 7th month after NNK injection, lung tissue samples were collected. Immunohistochemistry in accordance with the immunoblotting techniques were used to confirm the over-expression of phosphorylated MARCKS in the NNK induced lung cancer mice model. The present study concludes that the phosphorylated MARCKS was over-expressed in the NNK induced lung cancer mice during the early stages of lung cancer and it may be used as a tool to detect the lung cancer in the initial stages