Open Access<i>In vitro</i> antimicrobial evaluation of pyrazolone derivatives
Author(s) -
Leile Rahimi Ahar,
Moayad Hossaini Sadr,
Karim Zare,
Samad Motameni Tabatabaei
Publication year - 2015
Publication title -
bangladesh journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.385
H-Index - 23
eISSN - 1991-0088
pISSN - 1991-007X
DOI - 10.3329/bjp.v10i1.21166
Subject(s) - pyrazolone , minimum inhibitory concentration , antimicrobial , antibacterial activity , chemistry , bacillus subtilis , minimum bactericidal concentration , agar diffusion test , agar , bacteria , nuclear chemistry , in vitro , gram positive bacteria , organic chemistry , biochemistry , biology , genetics
In this investigation, unsubstituted pyrazolin-3(5)-ones (MePzO= 3-methyl-5-pyrazolone, PrPzO= 3-propyl-5-pyrazolone and PhPzO= 3-phenyl-5-pyrazolone) have been synthesized. The synthesized compounds were also screened for their antibacterial activity against some Gram-positive and Gram-negative bacteria using agar well diffusion method. The compounds with different concentrations were prepared and the activity was determined by measuring the diameter of the inhibition zone (in mm). The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of the compounds were determined against six bacteria. The antibacterial activities were influenced functional groups (methyl, propyl and phenyl). PhPzO exhibited the strongest activity (MIC, 0.625 mg/mL; MBC, 2.5 mg/mL) against Bacillus subtilis