Open AccessAssociation of Serum Ceruloplasmin Level with Parkinson’s’s Disease
Author(s) -
Md Zahidul Islam,
Kanuj Kumar Barman,
Md. Ahsan Habib,
Md. Rafiqul Islam,
Md. Rakibul Hasan,
Md. Kamrul Islam,
Muhammad Rezeul Huq,
Imran Sarker,
Ajay Kumar Agarwalla
Publication year - 2018
Publication title -
bangladesh journal of neuroscience
Language(s) - English
Resource type - Journals
eISSN - 2408-8382
pISSN - 1023-4853
DOI - 10.3329/bjn.v34i2.57547
Subject(s) - ceruloplasmin , parkinson's disease , substantia nigra , oxidative stress , pathogenesis , disease , medicine , neurology , case control study , endocrinology , homeostasis , psychiatry
Background: Parkinson’s disease, though a common neurodegenerative disease, is still elusive regarding its pathobiology. Neuronal degeneration in the midbrain substantia nigra by excess oxidative stress may play a role. As ceruloplasmin (Cp), a plasma protein is important to maintain intracellular iron homeostasis and reduce cellular oxidative stress, decreased serum Cp level may be an important factor in the pathogenesis of Parkinson’s disease.Methods: This case-control study was conducted in the department of Neurology, BSMMU. Forty-five Parkinson’s disease patients and equal number of controls were selected. Serum ceruloplasmin level was measured in the department of Biochemistry and Molecular Biology, BSMMU.Results: Mean serum Cp level was significantly lower (p-value <0.001) in case (27.64 mg/dl) than in control group (33.10 mg/dl).Conclusion: The association of low serum Cp level with Parkinson’s disease may indicate a possible iron homeostasis abnormality as a pathogenic factor in Parkinson’s disease.Bangladesh Journal of Neuroscience 2018; Vol. 34 (2): 63-65