Open AccessThe Effect of L-Carnitine and Proinflammatory Cytokines in the Development of Nonalcoholic Steatohepatitis
Author(s) -
Tetyana Dmitrivna Zvyagintseva,
Svetlana Vladimirovna Glushchenko
Publication year - 2016
Publication title -
bangladesh journal of medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.255
H-Index - 10
eISSN - 2079-6854
pISSN - 2076-0299
DOI - 10.3329/bjms.v15i1.20660
Subject(s) - carnitine , medicine , proinflammatory cytokine , tumor necrosis factor alpha , inflammation , immunoassay , steatosis , endocrinology , immunology , antibody
Objective: research is to study the role of L-carnitine, tumor necrosis factor ? (TNF-?), and interleucine-6 (IL-6) in the development of NASH.Materials and Methods: examined 65 patients with NASH. Blood serum L-carnitine, TNF-? and IL-6 level was estimated using the enzyme-linked immunoassay method.Results: patients with NASH had a decreased blood serum level of L-carnitine. L-carnitine level was found to be in strong inverse correlation dependence on cellular damage markers, L-carnitine levels affect the performance TNF-? and IL-6.Conclusion: L-carnitine contributes to lipotoxic stress development and development of systemic liver inflammation.Bangladesh Journal of Medical Science Vol.15(1) 2016 p.62-65