Open AccessDistribution of HLA-B Locus Antigens in Patients with Psoriatic Arthritis in Bangladesh
Author(s) -
Devolina Bhowmik,
Ruhul Amin Miah,
Shirin Tarafder,
Ahmed Abu Saleh,
Manash Chandra Sarker
Publication year - 2018
Publication title -
bangladesh journal of medical microbiology
Language(s) - English
Resource type - Journals
eISSN - 2072-3105
pISSN - 2070-1810
DOI - 10.3329/bjmm.v12i2.51691
Subject(s) - human leukocyte antigen , locus (genetics) , immunology , psoriatic arthritis , typing , allele , antigen , medicine , hla b antigens , ankylosing spondylitis , polymerase chain reaction , hla b , biology , psoriasis , genetics , gene
This study was designed to investigate the distribution of HLA-B locus antigens in patients with psoriatic arthritis (PsA) in Bangladesh and identify HLA markers related to disease manifestation in PsA. HLA-B typing was carried out by polymerase chain reaction (PCR) with sequence specific primers in a group of 50 consecutive PsA patients. The reports of HLA-B locus antigens typing were collected from 50 ages and sex matched unrelated healthy donors as controls. A total of 17 HLA-B locus antigens were determined in both patients and controls. The most common antigen was B*15 (34%) followed by B*07 (26%), B*27 (24%), B*38 (20%). Human leukocyte antigens B*07, B*27 and B*38 alleles were found to be significantly prevalent in PsA patients compared with healthy controls. We found a statistically significant association between spondylitis pattern and the presence of HLA-B*27. PsA in Bangladeshi patients seems to be associated with the presence of B*07, B*27 and B*38 alleles.
Bangladesh J Med Microbiol 2018; 12 (2): 14-20