Open AccessBioactivities of Adina cordifolia (Roxb.) Hook. f. - growing in Bangladesh
Author(s) -
Faiza Tahai,
Al Amin Sikder,
Abdullah Al-Mansur,
Mohammad A. Rashid
Publication year - 2019
Publication title -
bangladesh journal of botany
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.152
H-Index - 17
eISSN - 2079-9926
pISSN - 0253-5416
DOI - 10.3329/bjb.v48i2.47672
Subject(s) - tinospora cordifolia , traditional medicine , bark (sound) , umbelliferone , chemistry , carbon tetrachloride , agar diffusion test , antibacterial activity , biology , bacteria , coumarin , medicine , organic chemistry , ecology , genetics
A total of three compounds were isolated from the methanol extract of bark of Adina cordifolia (Roxb.) Hook. f. growing in Bangladesh and characterized as isoscopoletin (1), umbelliferone (2) and β-sitosterol (3) by analysis of high field NMR spectral data as well as co-TLC with authentic compounds. The minimum inhibitory concentration (MIC) of different extracts of bark of A. cordifolia was evaluated against three Gram positive and Gram negative pathogenic bacteria. The carbon tetrachloride soluble fraction showed the lowest MIC value (7.81 μg/ml) against Sarcina lutea as compared to 1.25 μg/ml for ciprofloxacin. The crude extract demonstrated significant antidiarrheal, hypoglycemic and peripheral analgesic activities at 200 and 400 mg/kg body weight in mice. On the other hand, the crude extract of bark of A. cordifolia revealed mild central analgesic activity.