Open AccessToxicological characteristics of diisodecyl phthalate Plasticiser
Author(s) -
Anastasiya V. Kharlamova,
V.F. Bogoyavlenska,
O.G. Bychova
Publication year - 2018
Publication title -
ukraïnsʹkij žurnal sučasnih problem toksikologìï/ukraïnsʹkij žurnal sučasnih problem toksikologìï
Language(s) - English
Resource type - Journals
eISSN - 2663-9165
pISSN - 2663-4570
DOI - 10.33273/2663-4570-2018-81-1-57-62
Subject(s) - phthalate , plasticizer , toxicity , carcinogen , limiting , dimethyl phthalate , toxicology , reproductive toxicity , chemistry , environmental chemistry , organic chemistry , biology , engineering , mechanical engineering
Objective. Analysis and generalisation of literature data and own studies on the toxicological characteristics of diisodecyl phthalate, plasticiser — high molecular weight phthalate.Materials and methods. Study of toxicity parameters of diisodecylphthalate, plasticiser. The analytical review of scientific publications has been made using the abstract database of scientific libraries and text database of PubMed publications.Results. The paper provides a scientific analysis of literature and own studies on the parameters of acute, subchronic, chronic toxicity, and long-term effects of diisodecyl phthalate with various routes of entry into the body of experimental animals.Conclusions. Diisodecyl phthalate is characterised by low values in terms of acute toxicity on the body of experimental animals. Longterm administration of diisodecyl phthalate is associated with hepatotoxic effects. Embryotoxic and teratogenic effects are manifested in high concentrations, which is not a limiting criterion in the systematic assessment of the plasticiser safety. Mutagenic and carcinogenic effects have not been established.Key words: plasticiser, diisodecyl phthalate, toxicity, reproductive toxicity, mutagenicity, carcinogenic action.