Open AccessSurfactant Mediated Synthesis of Polyhydroxybutyrate (PHB) Nanoparticles for Sustained Drug Delivery
Author(s) -
Sanjeevikumar Padmanaban
Publication year - 2020
Publication title -
proceedings international
Language(s) - English
Resource type - Journals
ISSN - 2668-6384
DOI - 10.33263/proceedings21.041041
Subject(s) - polyhydroxybutyrate , polyhydroxyalkanoates , biocompatibility , fourier transform infrared spectroscopy , nanoparticle , drug delivery , nuclear chemistry , biodegradation , solvent , materials science , chemistry , dichloromethane , chemical engineering , pulmonary surfactant , organic chemistry , nanotechnology , biochemistry , bacteria , genetics , engineering , biology
Polyhydroxyalkanoates are produced by bacterial fermentation that contains ester as their functional group. Polymeric substances derived from living organisms are captivating owing to the fact of their adaptability, biocompatibility, and biodegradability. The main objective of this study is to develop polymeric nanoparticles through the nanoprecipitation method using the PHA extracted from Pseudomonas aeruginosa. In this study, PHA extracted was characterized and determined as Polyhydroxybutyrate. The PHA was further used to produce nanoparticles by nanoprecipitation method using Dichloromethane as a solvent and subjected to various characterizations such as Ultraviolet-Visible spectroscopy (UV-Vis), Fourier Infra-Red spectroscopy (FTIR), Field Emission Scanning Electron microscopy (FeSEM) and further tested for sustained drug release. Nanoparticles prepared by the nanoprecipitation method had a size with invariable dissemination. Curcumin loaded PHA nanoparticles displayed a competent antibacterial effect against Bacillus subtilis. A controlled drug release was exhibited.