Open AccessSynthesis, Characterization and Antimicrobial Activity of Ni(II), Zn(II), and Cd(II) Complexes of 3/4-Bromo-Benzoic Acid (Phenyl-Pyridine-2-yl-Methylene)-Hydrazide Ligand
Author(s) -
Someshwar Bhale,
Vinayak K. Gore,
Sunil U. Tekale,
Rajendra P. Pawar
Publication year - 2020
Publication title -
letters in applied nanobioscience
Language(s) - English
Resource type - Journals
ISSN - 2284-6808
DOI - 10.33263/lianbs94.15291537
Subject(s) - chemistry , methylene , monobasic acid , benzoic acid , ligand (biochemistry) , hydrazide , medicinal chemistry , octahedral molecular geometry , pyridine , stereochemistry , metal , polymer chemistry , organic chemistry , biochemistry , receptor
New transition metal complexes [Ni(L)2], [Zn(L)Cl], [Zn(L)2] and [Cd(L)2] were synthesized from 3-bromo-benzoic acid (phenyl-pyridin-2-yl-methylene)-hydrazide (3Bbpph) and 4-bromo-benzoic acid (phenyl-pyridin-2-yl-methylene)-hydrazide (4Bbpph) ligands and were characterized by different physicochemical and spectral studies - IR, elemental, UV Visible, 1H NMR spectra and mass analysis. The data revealed the presence of tetra-coordinate [Zn (L)Cl], whereas [Ni(L)2], [Zn(L)2], and [Cd(L)2] complexes consist of metal ion coordinated with two molecules of ligand to form octahedral geometry. The ligands act as monobasic, tridentate, and coordinated through enolate-O, azomethine-N, and pyridyl-N atoms. The antimicrobial activity of the ligands and metal complexes was investigated against Staphylococcus Aureus, Streptococcus Pyogenes, Escherichia coli, Salmonella typhi, Candida Albicans and Trichophyton Rubrum which revealed that the metal complexes exhibit greater activity than the parent ligands.