Open AccessFloating Microspheres Based Nizatidine Gastro Retentive Formulation to Control the Release of Drug
Publication year - 2020
Publication title -
letters in applied nanobioscience
Language(s) - English
Resource type - Journals
ISSN - 2284-6808
DOI - 10.33263/lianbs93.14091419
Subject(s) - zeta potential , methyl cellulose , drug delivery , drug , chromatography , microsphere , particle size , biomedical engineering , materials science , chemistry , pharmacology , nanotechnology , medicine , chemical engineering , nanoparticle , cellulose , organic chemistry , engineering
Present research aimed at formulation development and characterization of the floating drug delivery system of Nizatidine, a H2-receptor antagonist, widely prescribed in gastric ulcers and duodenal ulcers. Nizatidine loaded floating microspheres were developed by the solvent diffusion-evaporation method using polymers hydroxypropyl methylcellulose (HPMC) and microcrystalline cellulose (MCC) to prolong the gastric retention time of the drug for the therapeutic management of gastric disorders like ulcers. Further, the developed formulations were characterized for percentage yield, drug entrapment, floating behavior, shape and surface morphology, in vitro drug release, determination of particle size and Zeta potential, in vitro stability studies, and antimicrobial activity. The percentage yield of the different formulation was found to be a range of 75.65– 81.25%, drug entrapment efficacies of different formulations were in the range of 65.56- 75.65% w/w, formulation F4 of floating microsphere was found to be 178.5 nm, Zeta potential of optimized formulation F4 of floating microsphere was found -33.6 Mv, Surface morphology of formulation examines at two different magnification 55X which illustrate the smooth surface of Microspheres. The in vitro drug release pattern of Nizatidine loaded optimized floating microsphere was subjected to the goodness of fit test by linear regression analysis, and it was observed that ‘r’ values of microsphere were maximum for zero-order, i.e., 0.969 hence indicating drug release from formulations follow zero-order kinetics with non-fickian diffusion mechanism which in turn prolonged drug release. The antimicrobial activity of the optimized formulation showed clear fluid with no development of turbidity. It inferred better clearance from infection than plain drug solution at the same doses. Floating microspheres of Nizatidine as gastro retentive dosage forms precisely control the release rate of Nizatidine to a peculiar site and expedite an immense impact on health care.