Open AccessSynthesis, characterization, biological activity of Schiff bases derived from 3-bromo-4-methyl aniline and its potentiometric studies with Cu(II), Co(II) and Ni(II) ions
Author(s) -
Surbhi V. Upadhyay,
Raksha V. Zala,
Keyur D. Bhatt
Publication year - 2020
Publication title -
letters in applied nanobioscience
Language(s) - English
Resource type - Journals
ISSN - 2284-6808
DOI - 10.33263/lianbs92.10151021
Subject(s) - aniline , chemistry , schiff base , potentiometric titration , stability constants of complexes , nuclear chemistry , ionic strength , inorganic chemistry , medicinal chemistry , ion , polymer chemistry , organic chemistry , aqueous solution
Schiff bases namely, 3-bromo-4-methyl-N-(2-nitrobenzylidene)aniline; 3-bromo-4-methyl-N-(2,4,5-trimethoxybenzylidene)aniline; 3-bromo-N-(4-methoxybenzylidene)-4-methylaniline and N-(3-bromo-4-methylphenyl)-1-(1H-indol-3-yl)methanimine have been synthesized and characterized by elemental analysis, FT-IR, Mass and 1H-NMR spectroscopy. Schiff bases have been screened for Antimicrobial activity against bacteria and fungi by using MIC determination. Binary complexes of Co(II), Ni(II) and Cu(II) with Schiff bases in solution have been studied potentiometrically in 60:40 % (V/V) 1,4-dioxane-water system at constant temperature 27˚±0.5˚C and at an ionic strength of 0.1 M KNO3. The order of stability constant of formed binary complexes in solution was examined.