Synthesis and antitumor activity of new isolated and fused heterobicyclic nitrogen systems containing 1,3,4-thiadiazole moiety derived from N1,N2-diaryl hydrazine compound | Zendy

Abeer Nasseral-Romaizan | Zendy

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Synthesis and antitumor activity of new isolated and fused heterobicyclic nitrogen systems containing 1,3,4-thiadiazole moiety derived from N1,N2-diaryl hydrazine compound

Author(s) -

Abeer Nasseral-Romaizan

Publication year - 2020

Publication title -

letters in applied nanobioscience

Language(s) - English

Resource type - Journals

ISSN - 2284-6808

DOI - 10.33263/lianbs91.935940

Subject(s) - moiety , hydrazine (antidepressant) , chemistry , phenol , cytotoxicity , nitrogen , stereochemistry , elemental analysis , mass spectrum , carbon 13 nmr , medicinal chemistry , combinatorial chemistry , mass spectrometry , organic chemistry , biochemistry , in vitro , chromatography

New pyrazolyls and/ or 1,2,4-triazines bearing 1,3,4-thiadiazole moiety (3-10) have been synthesized via an interaction between 2-[5-(2-(4-chlorophenyl)hydrazineyl)-1,3,4-thiadiazol-2-yl]phenol and bi-oxygen/ chloro nitrogen compounds in different conditions. Former structures of the new systems have been established from their elemental and spectral data (FT-IR, 1H/ 13C NMR, Mass spectra). All the obtained compounds were evaluated against MCF7 cell line cytotoxicity and antitumor cells. Compounds 9>10>2>7>8>4>5>6 exhibited important action.

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