Open AccessSynthesis and antitumor activity of new isolated and fused heterobicyclic nitrogen systems containing 1,3,4-thiadiazole moiety derived from N1,N2-diaryl hydrazine compound
Publication year - 2020
Publication title -
letters in applied nanobioscience
Language(s) - English
Resource type - Journals
ISSN - 2284-6808
DOI - 10.33263/lianbs91.885891
Subject(s) - moiety , hydrazine (antidepressant) , chemistry , cytotoxicity , phenol , stereochemistry , nitrogen , elemental analysis , mass spectrum , medicinal chemistry , combinatorial chemistry , mass spectrometry , organic chemistry , biochemistry , in vitro , chromatography
New pyrazolyls and/ or 1,2,4-triazines bearing 1,3,4-thiadiazole moiety (3-10) have been synthesized via an interaction between 2-[5-(2-(4-chlorophenyl)hydrazineyl)-1,3,4-thiadiazol-2-yl]phenol and bi-oxygen/ chloro nitrogen compounds in different conditions. Former structures of the new systems have been established from their elemental and spectral data (FT-IR, 1H/ 13C NMR, Mass spectra). All the obtained compounds were evaluated against MCF7 cell line cytotoxicity and antitumor cells. Compounds 9>10>2>7>8>4>5>6 exhibited important action.