Open AccessA Facile Synthesis of New Substituted Thiazol-2-amine Derivatives as Potent Antimicrobial Agent
Publication year - 2022
Publication title -
letters in applied nanobioscience
Language(s) - English
Resource type - Journals
ISSN - 2284-6808
DOI - 10.33263/lianbs122.032
Subject(s) - antimicrobial , thiourea , thiazole , chemistry , candida albicans , antifungal , amine gas treating , combinatorial chemistry , antibacterial activity , derivative (finance) , organic chemistry , bacteria , microbiology and biotechnology , biology , genetics , financial economics , economics
A facile synthesis of a new thiazol-2-amine derivative as antimicrobial agent and condensation with substituted thiourea compounds to afford the corresponding substituted thiazole derivatives in excellent yields. All the reactions were completed within less reaction time at reflux temperature. According to the result obtained, the compounds 3b, 3d, 3e, 3f, 3g, 3i, 3l, and 3m were found the leader antimicrobial activity with the highest MIC values. The synthesized compound can be considered to develop new antimicrobial drug candidates. Amongst these, many compounds show better antibacterial and antifungal activity. The compounds 3b, 3d, 3e, 3l, and 3m exhibited significant antibacterial activity against B. subtilis, S. aureus, and E. coli. The compounds 3f, 3g, 3i show significant antifungal against fungal strains i.e., C. albicans, A. flavus and A. niger.