Open AccessIn Vitro and In Vivo Genotoxicity Analysis of Gold Nanoparticles
Publication year - 2021
Publication title -
letters in applied nanobioscience
Language(s) - English
Resource type - Journals
ISSN - 2284-6808
DOI - 10.33263/lianbs113.38263833
Subject(s) - genotoxicity , colloidal gold , in vivo , micronucleus test , clastogen , micronucleus , in vitro , chemistry , nanoparticle , microbiology and biotechnology , pharmacology , biology , nanotechnology , toxicity , biochemistry , materials science , genetics , organic chemistry
Gold nanoparticles have been well recognized for biomedical applications, especially cancer therapeutics. As a preliminary step, it is necessary to investigate the genotoxicity of gold nanoparticles under in vitro and in vivo conditions. In vitro, chromosomal aberration study results showed that gold nanoparticles of 5 mg/ml concentration did not increase the percentage of chromosomal aberration in human peripheral blood lymphocyte cells compared to the negative control. Gold nanoparticles were evaluated erythrocyte micronucleus formation by in vivo micronucleus assay, and results showed no apparent micronucleus formation in mice after 42h exposure of gold nanoparticles. Gold nanoparticles of 600 mg/kg (body weight) were non-clastogenic in swiss albino mice.