Hypoglucemic Effect Exerted by an Ethynyl-Phenylamino-Steroid-Pyrazole Derivative against Glucose Levels using a Diabetic Model

The research aimed to prepare an ethynyl-phenylamino-steroid-pyrazole derivative to evaluate their hypoglycemic activity in a diabetic model using either metformin or glibenclamide as controls. Besides, a theoretical analysis was carried out to evaluate estrone derivative interaction with either insulin receptor (3iga) or potassium channel (3w12). The results showed that steroid derivatives decrease glucose levels, and this effect was in a similar form to metformin. Besides, other data suggest that the ethynyl-phenylamino-steroid-pyrazole derivative could have a higher interaction with the 3iga protein surface compared with metformin. In conclusion, the hypoglycemic activity exerted by the ethynyl-phenylamino-steroid-pyrazole derivative against glucose levels is interesting. In this way, this compound could be a good candidate for the treatment of diabetes.