Open AccessSynthesis and Characterization of New Pyrazolopyrimidine Derivatives Incorporated to Benzothiaazole
Author(s) -
Mostafa I. Waly,
Eman H. Tawfik,
Ahmed A. Fadda
Publication year - 2021
Publication title -
letters in applied nanobioscience
Language(s) - English
Resource type - Journals
ISSN - 2284-6808
DOI - 10.33263/lianbs103.24292437
Subject(s) - benzothiazole , hydrazine (antidepressant) , cyanoacetamide , chemistry , isothiocyanate , derivative (finance) , methyl iodide , reagent , hydrate , phenyl isothiocyanate , elemental analysis , combinatorial chemistry , organic chemistry , medicinal chemistry , biochemistry , financial economics , economics
Reaction of 2-Amino-6-methyl benzothiazole with 1-cyano-acetyl-3,5-dimethylpyrazole afforded cyanoacetamide derivative (2). Compound 2 was used as the precursor for the synthesis of novel aminopyrazole derivative (5) by reaction with phenyl isothiocyanate and methyl iodide followed by addition of hydrazine hydrate. Treatment of aminopyrazole (5) with different reagents gave pyrazolopyrimidine derivatives (7-12). The newly synthesized compounds were characterized by elemental analysis and the use of spectral data (IR, 1H NMR, and MS).