Open AccessSimple and Reliable Method for the Estimation of Albendazole in Antiparasitic Drug Formulations
Author(s) -
Umesha K. Bhadraiah,
Manasa Chandramouli,
Vrushabendra Basavanna,
Srikantamurthy Ningaiah
Publication year - 2020
Publication title -
letters in applied nanobioscience
Language(s) - English
Resource type - Journals
ISSN - 2284-6808
DOI - 10.33263/lianbs102.22022206
Subject(s) - albendazole , iodometry , chloramine t , chromatography , acetic acid , broad spectrum , chemistry , antiparasitic agent , pharmacology , medicine , organic chemistry , combinatorial chemistry , surgery
From the literature survey, it is confirmed that there are only a few analytical methods for the determination of albendazole. The principle behind this investigation is to produce a simple, exact and quick method of titrimetry for the quantification of albendazole. Albendazole having an oral broad-spectrum biological activity present in pharmaceutical drugs is determined using a conventional and reliable iodometric method using chloramine-T as an oxidant. The method involves the oxidation of sulfur by chloramine-T in glacial acetic acid, followed by the iodometric determination of the unreacted chloramine-T.