Open AccessSynthesis and Biological Evaluation of Novel Thiazole Hydrazines as Antimicrobial and Antimalarial Agents
Author(s) -
Vinayak K. Gore,
Sunil U. Tekale,
Someshwar Bhale,
Dhanaji P. Rajani,
Abraham J. Domb,
Rajendra P. Pawar
Publication year - 2020
Publication title -
letters in applied nanobioscience
Language(s) - English
Resource type - Journals
ISSN - 2284-6808
DOI - 10.33263/lianbs101.18461855
Subject(s) - candida albicans , antimicrobial , thiazole , plasmodium falciparum , phenacyl bromide , quinine , chemistry , antimalarial agent , phenacyl , salicylaldehyde , hydrazine (antidepressant) , semicarbazone , microbiology and biotechnology , malaria , combinatorial chemistry , stereochemistry , biology , organic chemistry , biochemistry , schiff base , immunology
Synthesis of some novel thiazole hydrazine derivatives from thiosemicarbazones of salicylaldehyde and 5-chlorosalicylaldehyde with phenacyl bromide in ethanol under reflux condition is reported. The synthesized compounds were characterized by spectral analysis and further screened against - S. aureus, E. coli, P. aeruginosa, S. pyogenus bacteria, and against C. albicans, A. clavatus, and A. niger fungal strains. Most of the compounds were active against E. coli and C. albicans. Antimalarial screening against Plasmodium falciparum showed moderate to the good activity of the synthesized compounds but less than the standard quinine. One of the synthesized compounds (4c) exhibited promising antimalarial activity against Plasmodium falciparum with IC50 close to the standard quinine.