Open AccessSynthesis, characterization and study the biological evaluation of some Schiff base derivatives in the presence of lemon juice catalyst
Publication year - 2019
Publication title -
biointerface research in applied chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.216
H-Index - 11
ISSN - 2069-5837
DOI - 10.33263/briac94.187192
Subject(s) - catalysis , solvent , chemistry , melting point , schiff base , carbon 13 nmr , organic chemistry , antibacterial activity , base (topology) , nuclear chemistry , natural product , combinatorial chemistry , bacteria , polymer chemistry , mathematics , mathematical analysis , biology , genetics
In this project, we tried to synthesis derivatives of 4-(benzylidene) aminopyrimidine (I), (benzo[d]thiazol-2-ylimino) methylphenol (II), n-benzylideneazine (III) and n-benzylideneaniline (IV) with natural catalyst and solvent instead of chemical catalyst and solvent condition as green chemistry. The advantages of the use of natural catalyst without organic solvent are eco-friendly, affordable, very safe and easy reaction conditions. The synthesized product was characterized by melting point, IR, 1H NMR and 13C NMR spectra. All derivatives of 4-(benzylidene)aminopyrimidine (I) were tested against gram-positive and gram-negative bacteria by minimum inhibitory concentration (MIC) and disk diffusion methods for antibacterial activities.