Open AccessPreliminary results of the investigations regarding the association of transforming growth factor- beta1 (TGFB1) gene polymorphism to metabolic syndrome in a Romanian patients group
Author(s) -
А Никитин Станислав,
Tatiana Vassu-Dimov
Publication year - 2019
Publication title -
biointerface research in applied chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.216
H-Index - 11
ISSN - 2069-5837
DOI - 10.33263/briac93.974978
Subject(s) - snp , obesity , metabolic syndrome , genetic predisposition , diabetes mellitus , transforming growth factor , population , genetics , biology , genetic association , gene , polymorphism (computer science) , risk factor , single nucleotide polymorphism , medicine , bioinformatics , genotype , endocrinology , environmental health
Genetic factors have a variable impact in predisposition for common chronic diseases, such as those grouped as metabolic syndrome (MS). MS, obesity, type 2 diabetes and hypertension have a common factor, represented by the inflammatory processes. There are numerous susceptibility genes associated with inflammation and these diseases; one gene of them is transforming growth factor –beta1 (TGFB1) gene. The promoter SNP TGFb1 -509C>T (rs1800469) has been reported as the risk factor associated with diabetes, kidneyand heart diseases in European population. This work describes the distribution of this SNP in the MS and healthy groups from Romanian population. Our preliminary data could not confirm an association between MS and TGFb1 -509C>T.