Open AccessPreparation of two steroid derivatives and its theoretical interaction with a 17β‐hydroxysteroid dehydrogenase type 1
Author(s) -
Lauro FigueroaValverde,
Camacho-Luis Abelardo,
Francisco Díaz-Cedillo,
RosasNexticapa Marcela,
MateuArmand Virginia,
Patricia Hernandez-Vasquez,
Pool-Gómez Eduardo,
LópezRamos Maria,
Hau-Heredia Lenin,
Tomás Joel LÓPEZ-GUTIÉRREZ,
Sarabia-Alcocer Bety,
Alfonso-Jimenez Alondra,
Cabrera-Tuz Jhair
Publication year - 2019
Publication title -
biointerface research in applied chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.216
H-Index - 11
ISSN - 2069-5837
DOI - 10.33263/briac91.800805
Subject(s) - steroid , dehydrogenase , hydroxysteroid dehydrogenase , chemistry , stereochemistry , hydroxysteroid dehydrogenases , combinatorial chemistry , biochemistry , enzyme , hormone
The aim of this study was synthesizing two steroid derivatives to evaluate their theoretical interact with a 17β‐hydroxysteroid dehydrogenase type 1. The first stage was achieved by the preparation of a steroid-imino analog (compound 2) using a reaction of imination and ii) etherification. Then, the theoretical interact of two steroid analogs with 17β‐hydroxysteroid dehydrogenase type 1 (1IOL) was evaluated using fisetin and methyl paraben as controls in a docking model. The results suggest that steroid derivatives could interact via a different type of aminoacid residues of 1IOL protein surface. However, the compound 2 showed a constant of inhibition lower compared with fisetin, methyl paraben and compound 3. All these data indicate that steroid derivative could act as 17β‐hydroxysteroid dehydrogenase type 1 inhibitor.