Preparation of two steroid derivatives and its theoretical interaction with a 17β‐hydroxysteroid dehydrogenase type 1 | Zendy

FigueroaValverde Lauro | Zendy; Camacho-Luis Abelardo | Zendy; Francisco Díaz-Cedillo | Zendy; RosasNexticapa Marcela | Zendy; MateuArmand Virginia | Zendy; Patricia Hernandez-Vasquez | Zendy; Pool-Gómez Eduardo | Zendy; López-Ramos María | Zendy; Hau-Heredia Lenin | Zendy; LopezGutierrez Tomas | Zendy; Sarabia-Alcocer Bety | Zendy; Alfonso-Jimenez Alondra | Zendy; Cabrera-Tuz Jhair | Zendy

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Preparation of two steroid derivatives and its theoretical interaction with a 17β‐hydroxysteroid dehydrogenase type 1

Author(s) -

FigueroaValverde Lauro,

Camacho-Luis Abelardo,

Francisco Díaz-Cedillo,

RosasNexticapa Marcela,

MateuArmand Virginia,

Patricia Hernandez-Vasquez,

Pool-Gómez Eduardo,

López-Ramos María,

Hau-Heredia Lenin,

LopezGutierrez Tomas,

Sarabia-Alcocer Bety,

Alfonso-Jimenez Alondra,

Cabrera-Tuz Jhair

Publication year - 2019

Publication title -

biointerface research in applied chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.216

H-Index - 11

ISSN - 2069-5837

DOI - 10.33263/briac91.800805

Subject(s) - steroid , dehydrogenase , hydroxysteroid dehydrogenase , chemistry , stereochemistry , hydroxysteroid dehydrogenases , combinatorial chemistry , biochemistry , enzyme , hormone

The aim of this study was synthesizing two steroid derivatives to evaluate their theoretical interact with a 17β‐hydroxysteroid dehydrogenase type 1. The first stage was achieved by the preparation of a steroid-imino analog (compound 2) using a reaction of imination and ii) etherification. Then, the theoretical interact of two steroid analogs with 17β‐hydroxysteroid dehydrogenase type 1 (1IOL) was evaluated using fisetin and methyl paraben as controls in a docking model. The results suggest that steroid derivatives could interact via a different type of aminoacid residues of 1IOL protein surface. However, the compound 2 showed a constant of inhibition lower compared with fisetin, methyl paraben and compound 3. All these data indicate that steroid derivative could act as 17β‐hydroxysteroid dehydrogenase type 1 inhibitor.

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