Magnetic scaffold for drug targeting: evaluation of cephalosporins controlled release profile

The great problem associated with drug administration is the inability to target aspecific area of the body. To reach an acceptable therapeutic level, large doses of thedrug must be administered. Only a part of the dose will actually reach the intendeddisease. Magnetic targeting simplifies drug administration procedures, increases theconcentration of the drug at target sites and decreases the concentration of the drug atnon-target sites. This study was focused to evaluate the controlled release profile ofcephalosporins from magnetic diethylaminoethyl-cellulose hybrid material (magneticscaffold). Dissolution behavior of these magnetic scaffolds was evaluated using amodified HPLC system. It was found that in all cases, at large time values, thecephalosporin’s concentration was much below the solubility plateau for the pure activecompound, demonstrating that the adsorption on the surface of magnetic scaffolds is avaluable procedure to attain controlled release