Open AccessAn Overview on the Pathophysiological Roles of microRNA- 802: a Literature Review
Author(s) -
Maryam Eini,
Jafar Kiani,
Elahe Seyed Hosseini,
Marziyeh Zarei,
Sepideh Parsi,
Mahmood Barati,
Golnaz Bahramali,
Arshad Hosseini
Publication year - 2022
Publication title -
biointerface research in applied chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.216
H-Index - 11
ISSN - 2069-5837
DOI - 10.33263/briac132.172
Subject(s) - microrna , gene silencing , biology , computational biology , gene , bioinformatics , disease , gene expression , medicine , genetics
Over the last two decades, microRNAs (miRNAs) have emerged as a novel class of small non-coding RNAs that fine-tune the expression of various target genes at a post-transcriptional level. Recent studies have highlighted the functional roles of miR-802 in different pathological and physiological conditions. By means of different molecular techniques, including high throughput and gene silencing ones, miR-802 aberrant expression and some of its targets and mechanisms of action have been determined in obesity, glucose metabolism, different types of cancers, Down syndrome, nephropathy, and immune system-mediated conditions. Herein, we review the current knowledge about promising applications of miR-802 in human diseases as biomarkers and therapeutic targets.