Open AccessConceptual Analysis of Microbial Processes and Drug Delivery System by the Active Ingredients of Nigella sativa
Publication year - 2022
Publication title -
biointerface research in applied chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.216
H-Index - 11
ISSN - 2069-5837
DOI - 10.33263/briac131.009
Subject(s) - nigella sativa , antimicrobial , thymoquinone , thymol , polyvinyl alcohol , chemistry , staphylococcus aureus , bacteria , antibacterial activity , drug delivery , food science , microbiology and biotechnology , traditional medicine , biology , organic chemistry , antioxidant , medicine , essential oil , genetics
Many natural plants have potential components having antiviral and antibacterial properties. Nigella sativa (N. sativa) components have been selected to observe the antiviral and antibacterial characteristics. Seed of Nigella contains thymoquinone (TQ), dithymo-quinone (DTQ), thymo-hydroquinone (THQ), p-cymene, and thymol (THY). The neutralization process of viral proteins by TQ and THQ has been demonstrated in this study. The interaction of N. sativa nanoparticles on bacteria cells was discussed. N. sativa electrospun nanofibrous membranes have diverse merits. These include easily adjustable structure, high surface area, and adjustable diameter, good pore connectivity, and high porosity, which give broad application prospects in drug delivery systems. Nanofibrous membrane produced from an electrospinning machine from nigella extract with polyvinyl alcohol (PVA) solution for potential application as the interaction of N. sativa nanoparticles on drug delivery systems and bacteria cells were discussed. The disk diffusion approach was applied to analyze the antimicrobial activity of the PVA-nigella membrane against the bacteria, namely Staphylococcus aureus (S. aureus), and the inhibition zone with an outcome of 15 mm is found.