Open AccessBioactive Compounds of Softwood Bark as Potential Agents against Human Diseases Include the SARS-CoV-2 Virus
Author(s) -
Petra Strižincová,
Michal Jablonský,
M. Lelovský
Publication year - 2021
Publication title -
biointerface research in applied chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.216
H-Index - 11
ISSN - 2069-5837
DOI - 10.33263/briac125.58605869
Subject(s) - bark (sound) , scots pine , picea abies , virus , biology , human health , sars virus , traditional medicine , medicinal plants , terpene , pharmacology , chemistry , covid-19 , pinus <genus> , virology , medicine , botany , biochemistry , ecology , disease , infectious disease (medical specialty) , pathology , environmental health
In recent years, significant progress has been achieved in developing natural drugs derived from medicinal plants. Multiple in-vitro screening studies reported that some naturally occurring compounds could possess inhibitory activity against various human viruses. The presented work describes significant biological activities of the main class of secondary metabolites such as phenolic compounds and terpenes located in industrially important tree species Norway spruce (Picea Abies) and Scots pine (Pinus Sylvestris). Phytochemicals show promising in vitro antiviral and cytotoxic activities, making them an attractive starting material for new development in various pharmaceutical products. They have the potential to effectively protect human health against cardiovascular diseases, diabetes mellitus, and as therapeutic agents against the SARS-CoV-2 virus.