Open AccessRadiation Dose Enhancement in Megavoltage Radiation Therapy using Au, Gd, Pt, Ag, and Bi Nanoparticles of Various Concentration Level
Author(s) -
Fouad A. Abolaban,
Andrew Nisbet
Publication year - 2021
Publication title -
biointerface research in applied chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.216
H-Index - 11
ISSN - 2069-5837
DOI - 10.33263/briac122.24042414
Subject(s) - imaging phantom , radiation therapy , materials science , radiation , monte carlo method , nuclear medicine , irradiation , linear particle accelerator , radiochemistry , biomedical engineering , beam (structure) , optics , physics , chemistry , medicine , radiology , mathematics , nuclear physics , statistics
A digital phantom was created from a CT scan of a patient’s head and employed together with GATE 8.2 Monte Carlo modeling of a linear accelerator of nominal 6 MV energy to simulate an irradiation geometry for a typical tumor volume centrally within the brain region. Although simplistic in arrangement, this setup was considered appropriate to demonstrate the dose enhancements that may be expected for megavoltage external beam radiation therapy for nanoparticles (NP) of different elemental composition and concentration. Ag, Gd, Pt, Au and Bi were modeled in concentrations varying from 15 mg NP / gram tissue to 70 mg NP / gram tissue. The maximum Average Dose Enhancement Factor (ADEF) to the Gross Tumour Volume (GTV) observed was 3 % for 70 mg NP / gram tissue of Bi.