Open AccessRheological Properties of Hyaluronic Acid Diluted Solutions as Components of Cosmetics
Author(s) -
Svetlana Saitarly,
Yuriy Pushkarev,
Mariia Nesterkina,
Serpil Öztürk,
Bekir Salih,
Iryna Kravchenko
Publication year - 2021
Publication title -
biointerface research in applied chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.216
H-Index - 11
ISSN - 2069-5837
DOI - 10.33263/briac122.19071915
Subject(s) - rheology , dispersity , viscosity , chemistry , hyaluronic acid , aqueous solution , molecular mass , chromatography , chemical engineering , materials science , polymer chemistry , organic chemistry , composite material , biology , engineering , genetics , enzyme
Rheological measurements were carried out on dilute aqueous solutions of high (HMW-HA, 1150 kDa) and low molecular weight hyaluronic acids (LMW-HA, 8 kDa) along with their mixtures to determine the relationship between the viscosity and concentration of the samples. Molecular weight and polydispersity of low molecular HA have been determined by matrix-assisted laser desorption ionization mass spectrometry (MALDI-MS). HA diluted solutions were found to be weakly structured liquids with a slight viscosity anomaly. Critical values of concentration were determined at different ratios of HMW-HA and LMW-HA, leading to a sharp increase in the viscosity of solutions. Rheological studies have proved the pseudoplastic nature of the viscous flow of HMW-HA solutions. The possibility of using the Ostwald-de Waele equation for the mathematical description of a viscous flow was established. The results of the rheological analysis might be applied for the rational development of cosmetic formulations containing hyaluronic acid of various molecular weights.