Open AccessApplying Nanotechnology in the Synthesis of Benzimidazole Derivatives: A Pharmacological Approach
Publication year - 2021
Publication title -
biointerface research in applied chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.216
H-Index - 11
ISSN - 2069-5837
DOI - 10.33263/briac121.9921005
Subject(s) - benzimidazole , combinatorial chemistry , moiety , imidazole , chemistry , azole , antimicrobial , nanotechnology , pharmacology , organic chemistry , medicine , antifungal , materials science , dermatology
Benzimidazoles are classified as a category of heterocyclic compounds. They possess an essential structural feature of 6-membered benzene fused to 5-membered imidazole moiety. Molecules having benzimidazole motifs confirmed promising utility in organic and scientific studies. Various pharmacological residences were explored with a strong inhibitor of numerous enzymes. They are concerned with being efficient antidiabetic, anticancer, antimicrobial, antiparasitic, analgesics, antiviral and antihistaminic agents. Moreover, they can be utilized in cardiovascular disease, neurology, endocrinology, and ophthalmology. The multiple activities for benzimidazole compounds have emerged due to their stability, bioavailability, and good-sized organic activity. Modifications of some organic polymers were carried out by utilizing different azole moieties. This review is devoted to mention some of the various current techniques for the synthesis of benzimidazole derivatives and their pharmacological residences with representing numerous derivatives.