Open AccessHepatoprotective and Haematoprotective Roles of Gongronema latifolium Benth Aqueous Extract in Alloxan-Induced Diabetic Rats
Publication year - 2021
Publication title -
biointerface research in applied chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.216
H-Index - 11
ISSN - 2069-5837
DOI - 10.33263/briac121.537546
Subject(s) - alloxan , body weight , metformin , traditional medicine , aqueous extract , diabetes mellitus , albumin , medicine , medicinal plants , pharmacology , endocrinology
This research evaluates the hepatoprotective and haematoprotective abilities of the extract of Gongronema latifolium leaves in diabetic rats. Forty animals were induced intraperitoneal using alloxan of 150 mg/kg body weight. The Wistar rats were thereafter divided as follows: normal control, diabetic untreated control, diabetic rats received 5 mg/kg body weight of metformin, and diabetic rats received three ethnobotanical doses (6.36, 12.72, and 25.44 mg/kg body weight) of aqueous extract of G. latifolium leaves (AEGLL). On the 14th day of the experiment, the rats were relinquished, and various hepatoprotective and haematoprotective biomarkers were assessed. Diabetic rats administered AGELL demonstrated normoglycaemia, reduced inflammatory levels as well as activities of transaminases. Also, diabetic animals that received AGELL show a substantial increase in protein, albumin, and hematological parameters determined when linked to diabetic control rats. Hence, three ethnobotanical doses revealed the hepatoprotective and haematoprotective nature of this plant.