Protective Effects of Spirulina against Cyclophosphamide Induced Bone Marrow Toxicity in Mice

Spirulina Platenesis (Sp) is rich in important compounds with antioxidant effects. This study investigates the treatment and prophylactic effect of Spirulina Platenesis (Sp) against Cyclophosphamide (CP) induced bone marrow toxicity. Fifty female BALB/C mice were randomly classified into 5 equal groups: (1) Normal controls; (2) CP group: injected with 40 mg/kg for 10 days; (3) Sp group: supplied by Sp (1000 mg/kg) for 10 days; (4) Treatment group: CP + Sp; (5) Prophylactic group: Sp + CP. After 10 days, At the end of the study period, all rats were killed, blood was withdrawn, and bone marrow (BM) was subjected to investigation. Cyclophosphamide administration caused rapid dimension in CBC parameter, Bone marrow WBC count and Erythropiotein concentration in blood that have been recovered with Sp administration. According to histological analysis of the bone marrow, spirulina impaired the proliferation and hypercellularity of immature myeloid elements in the bone marrow, which CP decreased. Obviously, spirulina may with antioxidative activity reduced the oxidative stress and toxicity induced by cyclophosphamide in mouse bone marrow cells.