Open AccessGraphene Oxide as a Carrier for Drug Delivery of Methotrexate
Author(s) -
Hani Nasser Abdelhamid,
H. Kamal
Publication year - 2021
Publication title -
biointerface research in applied chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.216
H-Index - 11
ISSN - 2069-5837
DOI - 10.33263/briac116.1472614735
Subject(s) - graphene , drug delivery , cytotoxicity , methotrexate , transmission electron microscopy , drug , drug carrier , nanotechnology , targeted drug delivery , materials science , oxide , scanning electron microscope , nanomaterials , chemistry , pharmacology , medicine , biochemistry , in vitro , immunology , metallurgy , composite material
Nanomaterials, including carbon-based nanoparticles, have been applied as carriers for anticancer drugs. This short communication reported the synthesis, cytotoxicity, and drug delivery of methotrexate using graphene oxide (GO) as a carrier. GO was synthesized following Hummer's method. It was characterized using X-ray diffraction (XRD), transmission electron microscope (TEM), and scanning electron microscope (SEM). Data analysis confirms the synthesis of GO with high crystallinity and lamellae morphology. GO showed a high cytocompatibility toward the human EA.hy926 endothelial cells. GO has been used as a carrier for the anticancer drug; methotrexate. The drug delivery was tested for hepatocellular carcinoma cells (HepG2 cells), human embryonic kidney cells (HEK293A cells), and porcine skin fibroblasts (PEF).